Last edited by JoJotilar
Friday, July 31, 2020 | History

4 edition of The Macrophage as Therapeutic Target found in the catalog.

The Macrophage as Therapeutic Target

by Siamon Gordon

  • 15 Want to read
  • 18 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Medical,
  • Medical / Nursing,
  • Life Sciences - General,
  • Pharmacology,
  • Medical / Pharmacology,
  • drugs,
  • infection,
  • receptors,
  • Diseases,
  • Diseases - Viral,
  • Antigen Presentation,
  • Drug targeting,
  • Immunology,
  • Macrophages,
  • drug effects

  • Edition Notes

    HANDBOOK OF EXPERIMENTAL PHARMACOLOGY

    The Physical Object
    FormatHardcover
    Number of Pages400
    ID Numbers
    Open LibraryOL12775342M
    ISBN 103540442502
    ISBN 109783540442509

    The monocyte/macrophage lineage as a therapeutic target in Idiopathic Pulmonary Fibrosis Article (PDF Available) February with Reads How we measure 'reads'.   Macrophage surface markers can act as useful therapeutic targets. Mannose receptor CD can be exploited as a macrophage-specific target. A single-chain peptide bound to the CD receptor was attached to nanobodies that can selectively target CD + TAMs [ 11 ].

    Conclusion: Our results suggested that macrophage-associated lncRNA ELMO1-AS1 could be a crucial regulator involved in HCC progression and considered as a potential prognostic biomarker and therapeutic target for HCC. Keywords: long noncoding RNA, ELMO1-AS1, HCC, prognosis. Macrophage polarization deserves better investigations as the therapeutic target for the development of novel drugs against myocardial injury. Curr Drug Targets. ;19(6) doi: /

    New therapies are required to target hypoxic areas of tumors as these sites are highly resistant to conventional cancer therapies. Monocytes continuously extravasate from the bloodstream into tumors where they differentiate into macrophages and accumulate in hypoxic areas, thereby opening up the possibility of using these cells as vehicles to deliver gene therapy to these otherwise. Monocytes/macrophages recruited into the arterial wall during atherogenesis are crucial in the initiation and progression of atherosclerosis and play a fundamental role in the destabilization process that is the main causal event of acute coronary syndromes. In the present study, we investigated the effect of the mammalian target of rapamycin inhibitor everolimus on macrophage accumulation.


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The Macrophage as Therapeutic Target by Siamon Gordon Download PDF EPUB FB2

The Macrophage as Therapeutic Target H. Rosen (auth.), Professor Siamon Gordon (eds.) During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention.

The Macrophage as Therapeutic Target (Handbook of Experimental Pharmacology) rd Edition by Siamon Gordon (Editor) ISBN ISBN Why is ISBN important.

ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. The digit and digit formats both work. During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention.

Macrophages play a central role in a wide range of disease processes, from. During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention.

Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to.

ISBN: OCLC Number: Description: x, pages: illustrations ; 24 cm. Contents: General --Macrophage as a validated pharmaceutical target --Transcription factors that regulate macrophage development and function --Exploitation of macrophage clearance functions in vivo --Reaching the macrophages: routes of delivery --Antigen presenting cells and vaccine.

The M2-like phenotype of iron-handling macrophages means that their use as a therapeutic target must be considered differently to that of M1-like macrophages. With regard to MFe hi, Mhem, and M(Hb) macrophages, a potential use for SPIONs could be to induce an iron-recycling phenotype and/or increase their anti-inflammatory phenotype.

atherosclerosis. New approaches to inhibit lipid accumulation in macrophage foam cells and reduce inflammatory responses may be of therapeutic value in preventing coronary artery disease.

The macrophage foam cell as a target for therapeutic intervention ANDREW C. LI & CHRISTOPHER K. GLASS RVqxd 10/18/02 PM Page   Targeting macrophages: therapeutic approaches in cancer.

Willingham, S. et al. The CDsignal regulatory protein alpha (SIRPa) interaction is a therapeutic target for. Title: The Macrophage Stimulating Protein/Ron Pathway as a Potential Therapeutic Target to Impede Multiple Mechanisms Involved in Breast Cancer Progression VOLUME: 11 ISSUE: 9 Author(s):Kelsi L.

Kretschmann, Henok Eyob, Saundra S. Buys and Alana L. Welm Affiliation:Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Circle of Hope, Salt Lake City, UT.

The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target Author links open overlay panel V.

Gambardella a b 1 J. Castillo c 1 N. Tarazona a b F. Gimeno-Valiente a C. Martínez-Ciarpaglini b d M. Cabeza-Segura a S. Roselló a b D. Roda a b M. Huerta a A. Cervantes a b 2 T. Fleitas a b 2. The macrophage, as a cell, is now beginning to reach a full measure of therapeutic maturity in the application of the understanding of the particular rate-limiting roles that it plays in the maintenance of health or the induction of diseases.

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity Xenia Geeraerts et al. Front Immunol. Free PMC article Show details Front Immunol Actions. Search in PubMed Search in NLM Catalog Add to Search.

Mar 15; doi: /fimmu Proteins affecting macrophage cholesterol metabolism and transport, including ATP‐binding cassette (ABC) A1, ABCG1, acyl‐CoA:cholesterol acyltransferase (ACAT), apolipoprotein A‐1 (ApoA‐1), neutral cholesteryl ester hydrolase (NCEH) also regulate foam cell formation and are being developed as therapeutic targets by many pharmaceutical.

Macrophages that normally aid tumor growth express unique surface protein allowing targeted cancer therapy. Macrophages are white blood cells that accumulate in tumors, where they aid cancer progression.

Now scientists have identified a surface protein found only on the macrophages residing in tumors, exposing a target for precise tumor treatments. Therapeutic strategies targeting macrophages as tumour-promoting factors, and/or aimed at macrophage activation and re-education are.

Understanding hepatic macrophage heterogeneity, up to a single cell level, and the underlying mechanisms may help to develop novel macrophage subset-targeted therapies for liver disease.

The present Special Issue aims to deepen our understanding of the biology, pathogenic role, and therapeutic potential of macrophages in the liver.

Given their potent proinflammatory effects in tissues, macrophages are an obvious therapeutic target in antibody-mediated autoim-munity. Indeed, mice deficient in activating Fc γRs (13) or with macrophage-specific overexpression of the inhibitory Fc γRIIB show less severe autoantibody-induced nephritis (14).

These data suggest. HIV-1 entry into macrophages. First step of HIV-1 entry into target host cells involves virus ligand (virus surface glycoprotein gp) and its interaction with CD4 receptor which is present in both T cells as well as in macrophages [14, 15] (Figure 1).Second step involves the fusion of viral envelope with host cell membrane which is governed by the engagement of the co-receptors (CCR5 or.

Human immunodeficiency virus (HIV) is still a serious global health concern responsible for more than 25 million deaths in last three decades. More than 34 million people are living with HIV infection.

Macrophages and CD4+ T cells are the principal. Get this from a library. The Macrophage as Therapeutic Target. [Siamon Gordon] -- During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for.

Given their potent proinflammatory effects in tissues, macrophages are an obvious therapeutic target in antibody-mediated autoimmunity. Indeed, mice deficient in activating FcγRs (13) or with macrophage-specific overexpression of the inhibitory FcγRIIB show less severe autoantibody-induced nephritis (14).T2 - a potential therapeutic target in IBD.

AU - Na, Yi Rang. AU - Stakenborg, Michelle. AU - Seok, Seung Hyeok. AU - Matteoli, Gianluca. PY - /9/1. Y1 - /9/1. N2 - Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate between innocuous antigens and potential pathogens to maintain oral tolerance.Buy The Macrophage as Therapeutic Target (Handbook of Experimental Pharmacology) Softcover reprint of the original 1st ed.

by Siamon Gordon (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders.